ACAT-1 INHIBITOR

摘要

PROBLEM TO BE SOLVED: To obtain an ACAT-1 inhibitor. SOLUTION: This ACAT-1 inhibitor comprises, as an active ingredient, a phosphonic acid diester derivative represented by formula (1) [wherein R1is a lower alkoxy group, a lower alkylamino group, an N,N-di-lower alkylamino group, a phenylamino group which may have 1-3 substituent groups selected from the group consisting of a halogen atom, a lower alkoxy group and a lower alkyl group on a benzene ring, a halogen atom, or the like, on a benzene ring; R2is hydrogen atom or a lower alkyl group; R3, R4, R5and R6are each the same or different and represent each hydrogen atom, a 2-7C alkanoyl group, nitro group, a halogen atom, a thiocyanate group, a lower alkyl group, a lower alkoxy group, hydroxy group or a halogen-substituted lower alkyl group; R7is hydrogen atom or a lower alkyl group; A is a ring selected from a benzene ring, a pyrazine ring and a thiophene ring or a lower alkylene]. COPYRIGHT: (C)2004,JPO