发明名称 |
Site-specific aminoglycoside derivatives and their use in immunodiagnostic assays |
摘要 |
A method of making a derivatized aminoglycoside includes reacting an aminoglycoside with at least 2 equivalents of a divalent metal ion in an aprotic solvent to complex two neighboring amino group and hydroxyl group pairs; reacting the non-complexed amino groups with a protecting reagent to provide protecting groups; removing the divalent metal ion to provide two unprotected amino groups; reacting one of the unprotected amino groups with a reactive substance containing an linker, a carrier, or a label; and removing the protecting groups. This method can be used to produce novel compounds and reagents.
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申请公布号 |
US6653456(B2) |
申请公布日期 |
2003.11.25 |
申请号 |
US20010920402 |
申请日期 |
2001.07.31 |
申请人 |
ROCHE DIAGNOSTICS CORPORATION |
发明人 |
GHOSHAL MITALI;SALAMONE SALVATORE J. |
分类号 |
A61K31/7008;C07H3/06;C07H5/06;(IPC1-7):C08B37/00;A61K31/715 |
主分类号 |
A61K31/7008 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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