发明名称 |
SOLUBLE ANALOGS OF PROBUCOL |
摘要 |
The invention provides a class of water-soluble probucol derivatives having one or more ester groups replacing the phenyl hydroxyl groups of the probucol molecule. Some derivatives have polar or charged functionalities such as carboxylic acid groups, amino groups, aldehyde groups and amide groups located on the ester groups. Some of these compounds are spontaneously hy- drolyzable in typical biological milieus. The present invention also provide s method of treating an animal with probucol by ad- ministering a water-soluble probucol prodrug to the animal.
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申请公布号 |
CA2134679(C) |
申请公布日期 |
2003.11.25 |
申请号 |
CA19932134679 |
申请日期 |
1993.04.30 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
PARTHASARATHY, SAMPATH |
分类号 |
A61K31/215;A61K31/10;A61K31/22;A61K31/222;A61K31/225;A61P3/06;A61P9/10;A61P31/12;A61P39/06;C07C319/20;C07C323/20;(IPC1-7):C07C323/20 |
主分类号 |
A61K31/215 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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