摘要 |
Crystalline monohydrate (I) of tiotropium bromide ((1alpha ,2beta ,4beta ,5alpha ,7beta )-7-(2-hydroxy-2,2-di(2-thienyl)acetoxy)-9,9-dimethyl-3-oxa-9-azonia-tricyclo[3.3.1.0 2>.4]nonane bromide) is new. An independent claim is also included for the preparation of (I). ACTIVITY : Antiinflammatory; antiasthmatic. MECHANISM OF ACTION : Anticholinergic. |