DERIVATISED PARTICULATE INHALATION CARRIERS

摘要

An inhalable composition comprising a particulate substrate having an average particle size of greater than 10 µm, comprising 5% or more of a derivatised carbohydrate compound, wherein the carbohydrate is derivatised at a hydroxyl, carboxylate or amine group with one or more groups individually selected from the group consisting of C1-24 alkyl, optionally substituted with one or more oxygen atoms in the carbon backbone, C2-24 acyl, C2-24 alkenyl and C6-32 aryl, any of which may be substituted with a halogen and/or a silicon atom; and a drug having a log P, where P is the partition coefficient between water and octanol, of greater than 1. A preferred example comprises particles of acetylated lactose with beclomethasone dipropionate. The compositions allow high drug levels in the composition and are suitable for delivery of drug to the lung.