| 摘要 |
<p>The invention relates to a recombinant chimeric protein comprising a fragment of 60 amino acids from the N-terminal region of the human interleukin 2 (IL-2) fused to the N-terminal of the extracellular region of the alpha chain of the receptor for IFN gamma (IFN η). Said in vitro protein exhibits T cell growth-stimulating activity, inhibits IL-2 growth-stimulating activity in T cells, inhibits the induction of HLA-DR by IFN η and inhibits the antiproliferative activity of IFN η. The invention is suitable for use in medicine for the treatment of various pathologies, such as autoimmune diseases, transplantation rejections, chronic inflammations, sepsis, ischemia and reperfusion syndrome and atherosclerosis.</p> |
