发明名称 |
PROCESS FOR THE PREPARATION OF 3-ISOCHROMANONE |
摘要 |
3-Isochromanone is prepared by partially chlorinating o-tolylacetic acid wit h sulphuryl chloride or chlorine gas in an inert organic solvent in the presen ce of a free radical initiator. The 2-chloromethylphenylacetic acid first obtained is converted to 3-isochromanone by treatment with a base and separated from unreacted o-tolylacetic acid, which is in the form of a salt, by a phase separation technique. The separated o-tolylacetic acid salt is converted to o-tolylacetic acid by controlled acidification and the o- tolylacetic acid is extracted for re-use. The invention reduces the formatio n of unwanted, over-chlorinated by-products and leads to a more efficient process.
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申请公布号 |
CA2485114(A1) |
申请公布日期 |
2003.11.20 |
申请号 |
CA20032485114 |
申请日期 |
2003.04.08 |
申请人 |
SYNGENTA LIMITED;SYNGENTA PARTICIPATIONS AG |
发明人 |
BUGNON, PASCAL;WHITTON, ALAN JOHN;JONES, RAYMOND VINCENT HEAVON;BENNIE, COLIN JOHN;RITCHIE, DAVID JOHN |
分类号 |
C07B61/00;C07D311/76;(IPC1-7):C07D311/76 |
主分类号 |
C07B61/00 |
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