METHODS OF SCREENING OF PP1-INTERACTING POLYPEPTIDES OR PROTEINS, PEPTIDES INHIBITING PP1c BINDING TO Bcl-2 PROTEINS, BCL-XL AND BCL-W, AND USES THEREOF

摘要

The invention relates to methods for identifying novel PP1-interacting polypeptides and proteins, compounds which are able to inhibit the binding of PP1 c to certain factors naturally interacting with it, especially proteins of the Bcl-2 family (such as Bcl-xL and Bcl-w), and pharmaceutical compositions comprising the same. The invention is based on the identification of a new PP1- binding motif having the sequence FXX[RKJX[RKJ, wherein X is any amino acid.