| 摘要 |
Compounds of formula (Ia) as potent, beta1-specific beta blockers with a short duration of action in the systemic circulation, wherein R is 3',4'-dimethoxyphenyl, R<1 >is hydrogen, and R<2 >is selected from methyl, ethyl, propyl, isobutyl and isopropyl; or R is 3',4'-dimethoxyphenyl, R<1 >is selected from fluorine, chlorine and bromine, and R<2 >is selected from methyl, ethyl, propyl, isopropyl, isobutyl and cyclopropylmethyl; of R is 4'-methoxyphenoxy, R<1 >is selected from hydrogen, fluorine, chlorine and bromine, and R<2 >is selected from methyl, ethyl, propyl, isopropyl, isobutyl and cyclopropylmethyl; or R is 3',4'-dimethoxyphenyl, R1 is cyano, and R<2 >is cyclopropylmethyl; or R is 4'-methoxyphenoxy, R<1 >is cyano, and R<2 >is isobutyl; and physiologically acceptable hydrolysable derivatives thereof having the hydroxy group in the 2-position of the 3-aminopropoxy side chain in esterified form, in their racemic and optically active forms, and their pharmaceutically acceptable acid addition salts.
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