METHOD FOR THE PREPARATION OF CRYSTALLINE TETRAHYDROBENZOTHIEPINES
摘要
Among its several embodiments, the present invention provides an improved process for the preparation of tetrahydrobenzothiepine-1,1-dioxide compounds; the provision of a process for preparing a diastereomeric mixture of tetrahydrobenzothiepine-1,1-dioxide compounds from a single diastereomer of such compounds; the provision of a process for the preparation of 3-bromo-2-substituted propionaldehyde compounds; the provision of a process for the preparation of 3-thio-2-substituted propionaldehyde compounds; and the provision of a process for the preparation of single crystals of ASBT inhibitors having high purity and low levels of solvent impurities.
申请公布号
WO03022804(A3)
申请公布日期
2003.11.20
申请号
WO2002US26877
申请日期
2002.08.23
申请人
G.D. SEARLE LLC;MUDIPALLI, PARTHA, S.;POZZO, MARK, J.;PARK, JUNG MIN
发明人
MUDIPALLI, PARTHA, S.;POZZO, MARK, J.;PARK, JUNG MIN