NEURONAL REGENERATION

摘要

Cl activators and/or C2 inhibitors can promote neuronal regeneration, even in the presence of the proteoglycans which compose glial rich scar tissue. Accordingly, the methods of the present application can be used to overcome the inhibitory effects of glial rich scar tissue, and thus be used to promote neuronal regeneration following tissue injury and/or degeneration, including tissue injury or degeneration which results in formation of a glial rich scar. The methods of the present application thus provide a novel treatment option for patients afflicted with any of a number of conditions which result in injury or degeneration of neuronal cells of the central and peripheral nervous system. Examples of conditions which can be treated by the methods described herein include, without limitation, spinal cord injury, brain injury (following surgery, stroke, cancer treatment, or trauma), peripheral nerve injury, Parkinson's disease, Huntington's disease, detached retina, macular degeneration, Alzheimer's disease, amotrophic lateral sclerosis (ALS), peripheral neuropathy, and diabetic neuropathy. One of skill in the art will appreciate that injuries or conditions that results in damage to or degeneration of neurons are candidates for treatment with the compositions of the present application.