| 摘要 |
The present invention is based on the discovery of an arthropod polypeptide which is a homologue of Macrophage Migration Inhibitory Factor (MIF). The present invention relates to the identification and characterization of a homologue of the proinflammatory cytokine, Macrophage Migration Inhibitory Factor in the tick, Amblyomma americanum. The invention provides MIF polypeptide, polynucleodites, antibodies that bind to MIF and methods of use for inducing immunity to ticks, thereby reducing the incidence of tick-borne infections in animals. It should be understood that immunity may also be induced to other species of ticks, including Haemaphysalis spp, Otobius spp, Rhiphicephalus spp, other Ambylomma spp, Dermacentor spp, Ixodes spp and Hyalomma spp and species of Boophilus.
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