| 摘要 |
FIELD: organic chemistry, chemical technology, pharmacy. SUBSTANCE: invention relates to derivatives of amide of the formula (I): wherein: R3 means C1-C6-alkyl or halogen atom; Q1 means heteroaryl that is optionally substituted with 1, 2, 3 or 4 substituents taken among the group including: hydroxy-, halogen atom, trifluoromethyl, cyano-, amino-, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C1-C6-alkoxy- and so on; R2 means hydroxy-, halogen atom, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C1-C6-alkoxy-; p = 0, 1 or 2; q = 0, 1, 2, 3 or 4; and Q2 means aryl, aryl-C1-C6-alkoxy-, aryloxy-, arylamino-, N-C1-C6-alkylarylamino-, aryl-C1-C6-alkylamino-, cycloalkyl, heteroaryl, heteroarylamino-, heteroaryl-C1-C6-alkylamino- or heterocyclyl and so on, or its pharmaceutically acceptable salt or cleaving in vivo ester. Invention proposes methods for preparing compounds of the formula (I). Also, invention proposes pharmaceutical composition eliciting activity inhibiting cytokines that comprises active component and pharmaceutically acceptable excipient or carrier. It comprises effective amount of derivative of amide of the formula (I) or its pharmaceutically acceptable salt, or cleaving in vivo ester as an active component. Invention provides preparing derivatives of benzamide that are effective as inhibitors of diseases mediated by cytokines. EFFECT: improved preparing method, valuable medicinal properties of compounds. 12 cl, 4 tbl
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