发明名称 |
COMPOSITIONS AND METHODS FOR SURROGATE ANTIBODY MODULATION OF AN IMMUNE RESPONSE AND TRANSPORT |
摘要 |
Methods and compositions for the modulation of an immune response are provided. Compositions comprise a bi-functional surrogate antibody molecule that interacts with a ligand of interest, wherein the bi-functional surrogate antibody further has attached thereto an immunomodulatory agent and/or a transporting agent. The compositions of the invention find use in a method for delivering an immunomodulatory agent to a ligand of interest. Further provided are methods for modulating an immune response in a subject against a ligand of interest. The method comprises administering a therapeutically effective amount of a bi-functional surrogate antibody of the invention. The methods of the invention also find use in improving the clinical outcome of a subject in need of a modulation in the immune response. Methods are further provided for the treatment or prevention of a variety of conditions and/or disorders including cancer, autoimmune diseases, allergies, prions, and various diseases or conditions of bacterial, parasitic, yeast or viral etiology.
|
申请公布号 |
WO03070192(A9) |
申请公布日期 |
2003.11.20 |
申请号 |
WO2003US05000 |
申请日期 |
2003.02.19 |
申请人 |
SYNTHERICA CORPORATION;FRIEDMAN, STEPHEN, B.;DRUTZ, DAVID, J. |
发明人 |
FRIEDMAN, STEPHEN, B.;DRUTZ, DAVID, J. |
分类号 |
C12N15/09;A61K31/739;A61K38/00;A61K39/395;A61K45/00;A61P1/02;A61P1/04;A61P3/10;A61P11/06;A61P17/06;A61P19/02;A61P21/04;A61P25/00;A61P29/00;A61P31/04;A61P31/10;A61P31/12;A61P31/18;A61P33/00;A61P35/00;A61P37/06;A61P37/08;C07K14/52;C07K16/00;C07K16/08;C07K16/12;C07K16/28;C07K16/30;C07K16/42;C07K16/44;C07K16/46;C07K19/00;C12P21/08;(IPC1-7):A61K/ |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|