ARALKYL FORMYL-ALKYL PIPERAZINE DERIVATIVES AND THEIR USES AS CEREBRAL NERVE PROTECTIVE AGENT
摘要
The invention relates to aralkyl formyl-alkyl piperazine derivatives, and the use of its compositions in the manufacture of medicaments for preventing or treating cerebral ischemic apoplexy and nerve protection, acting as central system excitable amino acid (N-methy-D-aspartic acid) antagonists (NMDA). The pharmacological experiments show that they display favorable full or ischemic anti-apoplexy activity, nerve protective activity and low side effects.
申请公布号
WO03095437(A1)
申请公布日期
2003.11.20
申请号
WO2003CN00273
申请日期
2003.04.16
申请人
SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY;LI, JIANQI;HUANG, LIYING;MIN, YANG;WENG, ZHIJIE;ZHANG, CHUNNIAN