发明名称 |
2-PHENYL BENZIMIDAZOLES AND IMIDAZO-[4,5]-PYRIDINES AS CDSI/CHK2-INHIBITORS AND ADJUVANTS TO CHEMOTHERAPY OR RADIATION THERAPY IN THE TREATMENT OF CANCER |
摘要 |
2-Aryl substituted benzimidazoles and imidazo[4,5]pyridines of formula (I) are disclosed as inhibitors of Cds1 and useful as adjuvants to chemotherapy or radiation therapy in the treatment of cancer. wherein W is COOH, -(CO)NHR<1>, or -(SO2)NHR<1> R<1> is H or C1-4alkyl; Q is N or CH; Ra and Rb are H or halogen; Y, Y1 and Y2 are independently selected from N and C-Rc with the proviso that 0, 1 or 2 of Y, Y1 and Y2 are N and at least 2 of Rc must be hydrogen; Rc are independently selected from the group consiting of -H, -OH, -C1-6alkyl, -SCF3, halo, -CF3 and -OCF3; Z is selected from the group consisting of O, S, SO, SO2, SO2NR<2>, NR<2>SO2, NH, CONR<2>, piperazin-diyl or a covalent bond; R<2> is H or C1-4alkyl; AR1 is an aromatic group as defined in the claims.
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申请公布号 |
WO03032984(A8) |
申请公布日期 |
2003.11.20 |
申请号 |
WO2002US33371 |
申请日期 |
2002.10.18 |
申请人 |
ORTHO-MCNEIL PHARMACEUTICAL,INC. |
发明人 |
ARIENTI,, KRISTEN, L.;AXE, FRANK, U.;BREITENBUCHER, J., GUY;HUANG, LIMING;LEE, ALICE;MCCLURE, KELLY, J. |
分类号 |
A61K31/4184;A61K31/437;A61K31/4439;A61K31/4745;A61K31/496;A61K31/497;A61K31/501;A61K31/506;A61K31/5377;A61K41/00;A61K45/00;A61P35/00;A61P43/00;C07D235/18;C07D401/04;C07D401/10;C07D401/12;C07D403/04;C07D405/12;C07D471/02;C07D471/04;(IPC1-7):A61K31/418;A61K31/443;A61K31/537;C07D295/12;C07D295/14 |
主分类号 |
A61K31/4184 |
代理机构 |
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