PHARMACEUTICAL COMPOSITION ELICITING THROMBOLYTIC AND FIBRINOLYTIC EFFECT

摘要

FIELD: medicine, pharmacy. SUBSTANCE: composition comprises the modified plasminogen activator of urokinase type mAPUT22 with specific activity 80 000-100 000 IU/mg of enzyme as an active substance that shows the definite amino acid sequence consisting of 403 amino acids and taken in the effective therapeutic dose and excipient also. Composition contains dextran with molecular mass 10 000-70 000 Da and sodium chloride as excipients. Composition can be used in ophthalmology. The novel composition shows the enhanced specific fibrinolytic and thrombolytic activity, it doesn't cause danger adverse effects in treatment of intraocular hemorrhages and fibrinous exudates arising in traumas and inflammatory diseases of eyes. EFFECT: enhanced effectiveness and valuable medicinal properties of composition. 5 cl