| 摘要 |
FIELD: chemical technology, pharmacy. SUBSTANCE: invention relates to method for preparing carvedilol of the formula (I) , its optically active R- or S-enantiomers, mixtures of these enantiomers and their pharmaceutically acceptable addition salts. Method involves interaction of 4-oxyranylmethoxy-9H-carbazole or its R- or S-enantiomers with N-[2-(2-methoxyphenoxy)ethyl]benzylamine in proton organic solvent and prepared benzyl-carvedilol is debenzylated by reaction of catalytic hydrogenation. Method allows increasing economical indices at the yield 80%. EFFECT: improved preparing method, enhanced yield. 4 cl, 13 ex
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