| 摘要 |
FIELD: pharmacy. SUBSTANCE: composition comprises mixture of itraconazole and phosphoric acid prepared by melting, pharmaceutically acceptable carrier and surface-active substance. The mass ratio of itraconazole to phosphoric acid is from 1 : 0.1 to 1 : 10. Composition provides the enhanced solubility of itraconazole in an aqueous solution from mixture prepared by melting as compared with solid intraconazole and the following enhancement of bioavailability of itraconazole in vitro. EFFECT: improved preparing method, enhanced and valuable medicinal properties of composition. 4 cl, 1 dwg, 1 tbl, 11 ex
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