N-amino carbonyl-piperazines analgesics - antiinflammatories ,hypotensives and spasmolytics

摘要

Compounds of formula (where R = alkyl or alkenyl of 1-4C straight or branched cycloaliphatic, or aromatic; R' = propyloxycarbonyl, dihydroxyethyl, or aminocarbonyl) are prepd. by treating cpds. of formula R-N=C=O with Prefd. compounds have R= CH3, C2H5, m-propyl, isopropyl, butyl, allyl, cyclohexyl or phenyl, and R' = pyrrolidinocarbonyl or isopropylaminocarbonyl. In an example, propyl isocyanate is treated with 1-(isopropylamino-carbonylmethyl) piperazine in tetrahydrofuran in the cold, and the product is converted into its maleate salt.