发明名称 |
Transgenic mouse expressing the human cyclooxygenase-2 gene and neuronal cell cultures derived therefrom |
摘要 |
The invention provides for transgenic mice whose genomes comprise a gene encoding human cyclooxygenase-2 under the control of a neuron-specific promoter. The transgenic mice of the instant invention express human cyclooxygenase-2 mRNA in neuronal cells of their hippocampi at increased levels relative to the level of human cyclooxygenase-2 mRNA expressed in their cerebral white matter. Moreover, neuronal cell cultures derived from the transgenic mice of the instant invention arc more susceptible to aggregated Abeta25-35 peptide-mediated impairment of redox activity relative to those derived from mice non-transgenic for the human cyclooxygenase-2 gene. These transgenic animals and the neuronal cultures derived therefrom are useful iii elucidating the pathophysiological bases of neurodegenerative diseases and in improving the diagnosis and treatment of these disorders.
|
申请公布号 |
US6649811(B2) |
申请公布日期 |
2003.11.18 |
申请号 |
US19990308424 |
申请日期 |
1999.07.16 |
申请人 |
|
发明人 |
|
分类号 |
A01K67/027;A61K31/18;A61P25/28;C12N5/02;C12N5/10;C12N9/02;C12N15/09;C12N15/85;(IPC1-7):A01K67/027;C12N5/00;C12N5/06 |
主分类号 |
A01K67/027 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|