发明名称 |
Mutant form of a cytotoxic ribonucleolytic protein which allows production by recombinant methods |
摘要 |
The present invention provides recombinant Onc (rOnc) compositions and methods. Recombinant Onc proteins of the invention have an amino terminal methionine and comprise an Onc polypeptide. The amino terminal methionine of the protein allows for recombinant production in a bacterial host cell. Cleaving the amino terminal methionine exposes the amino terminal glutamine of the polypeptide. The Onc polypeptide has an amino terminal glutamine. Cyclization of the amino terminal glutamine of the polypeptide to a pyroglutamyl residue provides rOnc polypeptides and proteins have anti-cancer and anti-viral activity.
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申请公布号 |
US6649392(B1) |
申请公布日期 |
2003.11.18 |
申请号 |
US19960626288 |
申请日期 |
1996.04.04 |
申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
YOULE RICHARD J.;VASANDANI VEENA M.;WU YON-NENG;BOIX ESTER;ARDELT WOJCIECH |
分类号 |
C07K14/46;C12N1/21;C12N9/22;C12N15/55;(IPC1-7):C12N9/22 |
主分类号 |
C07K14/46 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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