发明名称 |
Polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases |
摘要 |
Peptide conjugates in which cytocidal and cytostatic agents, such as polyamine analogs or naphthoquinones, are conjugated to a polypeptide recognized and cleaved by enzymes such as prostate-specific antigen (PSA) and cathepsin B are provided, as well as compositions comprising these conjugates. Methods of using these conjugates in the treatment of prostate diseases are also provided.
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申请公布号 |
US6649587(B1) |
申请公布日期 |
2003.11.18 |
申请号 |
US20000561172 |
申请日期 |
2000.04.27 |
申请人 |
SLIL BIOMEDICAL CORPORATION |
发明人 |
FRYDMAN BENJAMIN;MARTON LAURENCE J. |
分类号 |
A61K38/00;A61K47/48;C07C45/46;C07D207/34;C07D219/10;C07D235/18;C07D295/185;C07D307/79;C07D307/92;C07D311/92;C07D317/70;C07D487/22;C07D493/04;C07K5/103;C07K7/06;(IPC1-7):A61K38/02;A61K38/05;A61K38/06;C07K5/06;C07K5/08 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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地址 |
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