发明名称 |
Process for the preparation of 1-benzyl-4(5,6-dimethoxy-1-indanon)-2-yl) methyl piperidine hydrochloride (Donepezil HCL) |
摘要 |
A process for the preparation of 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride (Donepezil HCl). 5,6-Dimethoxy-2-(pyridin-4-yl)methylene inda-1-one is hydrogenated with a noble metal oxide catalyst in an organic solvent at 20-50° C. and 10-45 psi gauge pressure. The resulting 4-[(5,6-dimethoxy-1-indanon)-2-yl]methyl piperidine is alkylated with an alkylating agent in an organic solvent at 30-80° C.
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申请公布号 |
US6649765(B1) |
申请公布日期 |
2003.11.18 |
申请号 |
US20030365717 |
申请日期 |
2003.02.12 |
申请人 |
USV LIMITED, BSD MARG. |
发明人 |
VIDYADHAR JOSHI SHREERANG;VENKATRAMAN NAIDU AVINASH;PANDURANG SUTAR RAJIV |
分类号 |
C07D211/22;(IPC1-7):C07D211/02;C07D211/08 |
主分类号 |
C07D211/22 |
代理机构 |
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