发明名称 ANTITUMOR AGENTS WITH THE USE OF HSV
摘要 <p>Antitumor agents, tumor immunity inducers, T cell activators, and dendritic cell activators, highly safe and capable of inducing an antitumor immune reaction enabling immunotherapy for cancer in such a way that an antitumor effect is exerted on human distant tumors such as metastatic tumors. Methods for treating cancer using such agents, inducers and activators are also provided. A herpes simplex virus (inactivated HSV) or herpes simplex virus glycoprotein D (HSVgD) etc. is used as an effective ingredient of such antitumor agents, tumor immunity inducers, T cell activators, and dendritic cell activators. A specific example of the above-mentioned inactivation treatment is the combination of the ultraviolet irradiation treatment at 4 J/m&lt;2&gt; for 30 min using 254 nm ultraviolet light and heat treatment at 56 DEG C for 30 min.</p>
申请公布号 AU2003231398(A1) 申请公布日期 2003.11.17
申请号 AU20030231398 申请日期 2003.05.02
申请人 KEIO UNIVERSITY 发明人 MASAHIRO TODA;YUTAKA KAWAKAMI;YUKIHIKO IIZUKA;YOKO UEDA;YOSHIHIRO IWAHORI
分类号 C12N5/06;A61K35/76;A61K38/00;A61K38/16;A61K39/245;A61P35/00;A61P35/04;A61P37/02;A61P43/00;C07K14/035;C12N7/04;(IPC1-7):A61K35/76 主分类号 C12N5/06
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