发明名称 |
VERFAHREN ZUR HERSTELLUNG VON 2-HYDROXY-4-METHYL- THIOBUTTERSÄURE MIT EINER NITRILASE |
摘要 |
Production of 2-hydroxy-4-methylthiobutyric acid (I) and/or its ammonium salt (Ia) from 2-hydroxy-4-methylthiobutyronitrile (II) comprises contacting (II) with an immobilised material having nitrilase (III) activity to generate (Ia), optionally converting this to free acid, and concentrating the product. Also new are: (1) an aqueous solution containing (I) and (Ia) at weight ratio (I)/[(I)+(Ia)] of 5-99.9, preferably 10-50,%; (2) a device for the process, as above, comprising reaction chambers containing immobilised (III) or host cells expressing (III), optionally an electrodialysis unit and a means of concentrating the final product; and (3) the plasmid pRPA-BCAT3 (CBS 998-96). |
申请公布号 |
AT253638(T) |
申请公布日期 |
2003.11.15 |
申请号 |
AT19970912254T |
申请日期 |
1997.10.24 |
申请人 |
AVENTIS ANIMAL NUTRITION S.A. |
发明人 |
FAVRE-BULLE, OLIVIER;PIERRARD, JEROME;DAVID, CHRISTOPHE;MOREL, PHILIPPE;HORBEZ, DOMINIQUE |
分类号 |
C12N15/09;C12N1/15;C12N1/21;C12N9/14;C12N9/78;C12N11/08;C12N15/55;C12P11/00;C12R1/01;C12R1/07;C12R1/66 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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