PREPARATION OF D-(-) -1-SUBSTITUTED PHENYL-2-DICHLORO-ACETOAMINO-3FLUORO-1-PROPANOL FROM L TYPE SUBSTITUTED PHENYL SERINE ESTER
摘要
This invention relates to the preparation of D-(-)-substituted phenyl-2-dichloroacetoamino-3-fluoro-1-propanol, the method involves using L type substituted phenyl serine ester extracted and purified from resolution waste liquid as raw material and through stepped reactions. The process is simple, high yielded, low costed and complete in configuration and is an effective and simple method of converting L type substituted phenyl serine ester to D type fluorothiamphenicol. The invention can prevent from disposing waste antimer produced in the resolution process of producing Florfenicol, reduce environmental pollution and has certain practical significance.
申请公布号
WO03093221(A1)
申请公布日期
2003.11.13
申请号
WO2002CN00354
申请日期
2002.05.27
申请人
SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, CHINESE ACADEMY OF SCIENCES;LIN, GUOQIANG;LEI, XINSHENG;HUANG, HAO;YU, XIAOMING;LI, RONG
发明人
LIN, GUOQIANG;LEI, XINSHENG;HUANG, HAO;YU, XIAOMING;LI, RONG