Vaccine formulations and methods for immunizing an individual against shed antigen specific B cells

摘要

Provided are methods for inducing an immune response reactive with idiotypes on shed antigen-specific B cells in an individual by administering an immunologically effective amount of a vaccine formulation. Also provided are vaccine formulations comprising one or more peptides, wherein a peptide comprises an idiotype of an antibody that binds to an epitope of shed antigen; or one or more polynucleotides, wherein a polynucleotide encodes a peptide comprising an idiotype of an antibody that binds to an epitope of shed antigen.