CRYSTAL STRUCTURE OF ACETYL CHOLINE BINDING PROTEIN

摘要

The present invention relates to a crystal of a water-soluble ligand-binding protein, Le of the Acetyl Choline Binding Protein of Lymnaea stagnalis disclosed in International Patent Application PCT/EPOl/01457, preferably in a multimeric form such as dimer, pentamer or decamer. In one embodiment said crystal comprises a protein-ligand complex. The crystal structure can be used to generate 3D models of the extracellular ligand-binding domain of ligand­gated ion channels and thus for screening of drugs that act on these channels.