OCULAR DRUG DELIVERY SYSTEMS AND USE THEREOF

摘要

The invention provides a microsphere formulation for the sustained delivery of an aptamer, for example, an anti-Vascular Endothelial Growth Factor aptamer, to a preselected locus in a mammal. In addition, the invention provides methods for making such formulations, and methods of using such formulations to deliver an aptamer to a preselected locus in a mammal. In particular, the invention provides a method for delivering the aptamer to a scleral surface of an eye for the treatment of an ocular disorder, for example, age-related macular degeneration.