Dispersions of lipid particles for use as therapeutic and cosmetic agents and intracellular delivery vehicles

摘要

In a dispersion of lipid particles in a dispersing medium, the said lipid particles comprising an amino-amidine compound A, the amidine function of the said compound A is titrated substantially in water by means of an acid HX, wherein X is an anion, in a manner such that the pH of the said lipid dispersion is between about 6.5 and 7.8 within a temperature range from about 2° C. to 40° C. The so titrated dispersion is useful inter alia as a component of a synthetic vector for therapeutic molecules or macromolecules.