发明名称 |
Bile acid containing prodrugs with enhanced bioavailabilty |
摘要 |
Many compounds have poor bioavailability or variable bioavailability because of poor absorption of the compound in the small intestine. Conjugation of the compound with bile acid to form a prodrug will increase the bioavailibility of the compound and/or reduce the bioavailability variability of the compound because of the active transport of the prodrug by the intestinal bile acid transporter and because of increased lipophilic nature of the prodrug. A linker group can be used between the bile acid and the compound. One example of a bile acid containing prodrug is acyclovir valylchenodeoxycholate, where valine is the linker group. Another example of this prodrug is atenolol cholic acid amide.
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申请公布号 |
US2003212051(A1) |
申请公布日期 |
2003.11.13 |
申请号 |
US20030240859 |
申请日期 |
2003.03.21 |
申请人 |
POLLI JAMES E;COOP ANDREW;MAEDA DEAN Y;LENTZ KIMBERLY A |
发明人 |
POLLI JAMES E;COOP ANDREW;MAEDA DEAN Y;LENTZ KIMBERLY A |
分类号 |
C07J41/00;(IPC1-7):A61K31/56;A61K31/58 |
主分类号 |
C07J41/00 |
代理机构 |
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