ANTIBODY TO HUMAN INSULIN-LIKE GROWTH FACTOR

摘要

To efficiently treat diseases such as cancer in which hIGF participates, the re have been required antibodies which strongly bind to both of hIGF-I and hIGF - II and inhibit their functions and fragments of these antibodies. It is intended to provide antibodies which can specifically bind respectively to human IGF-I and human IGF-II to thereby inhibit the functions of human IGF-I and human IGF-II and have binding activity with a binding constant of 5.times.109 M-1 or more measured with a biosensor BIACORE. It is also intend ed to provide diagnostics, preventives and remedies comprising the above antibodies for an hIGF-mediated disease and a disease showing pathological progressing due to abnormally accelerated hIGF production.