摘要 |
It is intended to provide compounds inhibiting the autophosphorylation of macrophage colony stimulating factor receptor. Thus, compounds of the following general formula (I), salts thereof and solvates of the same are provided. (I) wherein X represents CH or N; Z represents O or S; R<1>, R<2> and R<3> represent each H, optionally substituted alkoxy, etc.; R<4> represents H; R<5>, R<6>, R<7> and R<8> represent each H, halogeno, alkyl, alkoxy, trifluoromethyl, etc.; R<9> and R<10> represent each H, alkyl, etc.; and one of R<11> and R<12> represents H while the other represents alkyl and R<13> represents an optionally substituted carbon ring, a heterocycle, etc., or R<11> represents H and R<12> and R<13> together form a bicyclic carbon ring.
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申请人 |
KIRIN BEER KABUSHIKI KAISHA;KUBO, KAZUO;OHNO, HIROAKI;ISOE, TOSHIYUKI;NISHITOBA, TUYOSHI |
发明人 |
KUBO, KAZUO;OHNO, HIROAKI;ISOE, TOSHIYUKI;NISHITOBA, TUYOSHI |