STABILISED MRNA WITH AN INCREASED G/C CONTENT AND OPTIMISED CODON FOR USE IN GENE THERAPY

摘要

The invention relates to a pharmaceutical composition containing an mRNA which is stabilised by sequence modifications in the translated region and is optimised for the translation. The inventive pharmaceutical composition is especially suitable as a vaccine and as a therapeutic agent for tissue repair. The invention also relates to a method for determining sequence modifications used to stabilise mRNA and to optimise the translation of the same.