BUTYRYLCHOLINESTERASE POLYPEPTIDE VARIANTS WITH INCREASED CATALYTIC EFFICIENCY AND METHODS OF USE
摘要
The invention provides twenty-five butyrylcholinesterase variants having increased cocaine hydrolysis activity as well as the corresponding encoding nucleic acids. The invention also provides libraries of butyrylcholinesterase variants as well as libraries of the corresponding nucleic acids encoding butyrylcholinesterase variants. The invention further provides methods of hydrolyzing a cocaine-based butyrylcholinesterase substrate as well as methods of treating a cocaine-induced condition.
申请公布号
WO02064796(A8)
申请公布日期
2003.11.13
申请号
WO2001US50450
申请日期
2001.12.21
申请人
APPLIED MOLECULAR EVOLUTION, INC.;UNIVERSITY OF NEBRASKA MEDICAL CENTER;LOCKRIDGE, OKSANA;WATKINS, JEFFRY, D.;PANCOOK, JAMES, D.
发明人
LOCKRIDGE, OKSANA;WATKINS, JEFFRY, D.;PANCOOK, JAMES, D.