| 发明名称 |
Attenuated antibodies against CD 28 and their use |
| 摘要 |
<p>The present invention provides anti-CD28 antibodies which are defective in mitogenic activity (silenced anti-CD28 antibodies), methods of producing, compositions containing the antibody and methods of immunosuppression, inducing T-cell tolerance and treating organ and/or tissue transplant rejections.</p> |
| 申请公布号 |
CZ20031909(A3) |
申请公布日期 |
2003.11.12 |
| 申请号 |
CZ20030001909 |
申请日期 |
2001.12.14 |
| 申请人 |
FUJISAWA PHARMACEUTICAL CO., LTD. |
发明人 |
TSO J. YUN;HINTON PAUL;VASQUEZ MAXIMILIANO;TAMURA KOUICHI;HIGASHI YASUYUKI;SEKI NOBUO;UEDA HIROTSUGU |
| 分类号 |
C12N15/09;A61K39/00;A61K39/395;A61K45/00;A61P37/00;A61P37/06;A61P41/00;A61P43/00;C07K16/28;C07K16/46;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12P21/08;G01N33/53;(IPC1-7):A61K39/395;C12N15/00;C12N15/12;C12N15/13 |
主分类号 |
C12N15/09 |
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