发明名称 VECTOR MODIFIED BY SEQUENCE CODING FOR A SEQUENCE OF AMINO ACIDS CONTAINED IN A MAMMALIAN PROTEIN HAVING THE BIOLOGICAL ACTIVITY OF A MEMBRANE RECEPTOR, EXPRESSION OF THIS SEQUENCE IN TRANSFORMED UNICELLULAR CULTURES BY MEANS OF THIS VECTOR, PROCEDURE FOR STUDYING LIGANDS RECOGNIZING THESE RECEPTORS
摘要 The invention relates to a vector capable of being replicated in cultures of unicellular organisms, this vector containing a gene coding for a eukaryotic protein having the biological activity of a membrane receptor and interacting with a regulatory protein-called the G protein-able to bind molecules of guanosine triphosphate (GTP). The invention also relates to cell organisms transformed by the above vectors. It also relates to procedures for the detection of the capacity of a molecule to behave as a ligand for a receptor and a procedure for studying the affinity of a receptor for a ligand as well as a kit for detecting the possible affinity of a ligand for a receptor.
申请公布号 US6645755(B1) 申请公布日期 2003.11.11
申请号 US19950422612 申请日期 1995.04.13
申请人 CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE 发明人 MARULLO STEFANO;DELAVIER COLETTE;EMORINE LAURENT;STROSBERG DONNY
分类号 C12N1/21;C07K14/705;C12Q1/68;C12R1/19;(IPC1-7):C12N1/14;C12N1/16;C12N1/18 主分类号 C12N1/21
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