| 发明名称 |
Method of blocking blood vessel growth using tie-2 ligand 2 |
| 摘要 |
The present invention provides for an isolated nucleic acid molecule encoding a human TIE-2 ligand. In addition, the invention provides for a receptor body which specifically binds a human TIE-2 ligand. The invention also provides an antibody which specifically binds a human TIE-2 ligand. The invention further provides for an antagonist of human TIE-2. The invention also provides for therapeutic compositions as well as a method of blocking blood vessel growth, a method of promoting neovascularization, a method of promoting the growth or differentiation of a cell expressing the TIE-2 receptor, a method of blocking the growth or differentiation of a cell expressing the TIE-2 receptor and a method of attenuating or preventing tumor growth in a human.
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| 申请公布号 |
US6645484(B1) |
申请公布日期 |
2003.11.11 |
| 申请号 |
US20000689020 |
申请日期 |
2000.10.12 |
| 申请人 |
REGENERON PHARMACEUTICALS, INC. |
发明人 |
DAVIS SAMUEL;BRUNO JOANNE;GOLDFARB MITCHELL;ALDRICH THOMAS H.;MAISONPIERRE PETER C.;RADZIEJEWSKI CZESLAW;JONES PAMELA F.;YANCOPOULOS GEORGE D. |
| 分类号 |
G01N33/50;A61K38/00;A61K38/17;A61K39/395;A61K47/48;A61K48/00;A61K51/00;A61P9/10;A61P29/00;A61P31/04;A61P35/00;C07H21/04;C07K;C07K14/47;C07K14/515;C07K14/705;C07K16/28;C07K19/00;C12N;C12N5/06;C12N5/10;C12N15/00;C12N15/02;C12N15/09;C12N15/12;C12N15/19;C12N15/62;C12N15/63;C12P21/02;C12P21/08;C12R1/91;G01N33/53;(IPC1-7):A61K38/19 |
主分类号 |
G01N33/50 |
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