| 摘要 |
FIELD: organic chemistry, biochemistry. SUBSTANCE: invention relates to derivatives of aminobutyric, aminopentanoic and aminohexanoic acids of the general formula (I): wherein or Y-P--(OR51)2; m = 0, 1, 2; n = OD-3; each of R2, R3, R4, R5, R6, R7 is independently hydrogen atom, C1-8-alkyl, C2-8-alkenyl, -OR11, -SR11, -NR12R13, Cycle 1, C1-8-alkyl substituted with -OR11, -SR11, -NR12R13, -COR14, guanidine or Cycle 1, or C2-8-alkenyl substituted with -OR11, -SR11, -NR12R13, -COR14, guanidine or Cycle 1; or R3 and R4, taken in common represent C1-8-alkylene; R5 and R6, taken in common represent C1-8-alkylene; R3 and R6 taken in common represent C1-8-alkylene; R2 and R3, taken in common represent C2-8-alkylene; R4 and R5, taken in common represent C2-8-alkylene; or R6 and R7, taken in common represent C2-8-alkylene; or (1) R8 represents: 1) hydrogen atom; 2) C1-8-alkyl; 3) C1-8-alkoxycarbonyl; 4) C1-8-alkyl substituted with -OR26, -SR26, -NR27R28 or -COR29; or 5) C1-8-alkoxycarbonyl substituted with Cycle 2; and R9 represents ; (2) R8 represents: ; R9 represents: 1) C1-8-alkyl; C1-8-alkoxy; 3) C1-8-alkoxy substituted with Cycle 2; 4) C1-8-alkyl substituted with -OR26, -SR26, -NR27R28, -COR29 or Cycle 2, or: 5) ; A is C3-15-mono-, bi- or tricarbocyclic or 5-18- membered mono-bi- or tri-heterocyclic ring comprising from 1 to 4 nitrogen atoms, from 1 to 2 oxygen atoms and/or from 1 to 2 sulfur atoms or its nontoxic salts and to inhibitor of matrix metalloproteinase containing compound of the formula (I) as an active component. EFFECT: valuable biochemical properties of compounds. 15 cl, 106 tbl, 73 ex
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