| 摘要 |
The present invention is in the fields of biotechnology, protein purification and crystallization, x-ray diffraction analysis, three-dimensional computer molecular modeling and rational drug design. The invention is directed to the glucocorticoid receptor and ligands for this receptor, and in particular to crystalline glucocorticoid receptor (GR) and to methods of identifying ligands utilizing GR, as well as to compounds, compositions and methods for selecting, making, and using therapeutic or diagnostic agents having GR modulating or binding activity. |
| 申请人 |
KARO BIO AB;ABBOTT LABORATORIES;JAKOB, CLARISSA, G.;MUCHMORE, STEVEN;KAUPPI, BJOERN;FARNEGAARDH, MATHIAS;HARLAN, JOHN, E.;YANG, JIE,;CARLQUIST, MATS;ENGSTROEM, OWE;AHOLA, HARRI;OEHMAN, LARS |
发明人 |
JAKOB, CLARISSA, G.;MUCHMORE, STEVEN;KAUPPI, BJOERN;FARNEGAARDH, MATHIAS;HARLAN, JOHN, E.;YANG, JIE,;CARLQUIST, MATS;ENGSTROEM, OWE;AHOLA, HARRI;OEHMAN, LARS |
