NOVEL THIOL DERIVATIVE, PROCESS FOR PRODUCING THE SAME AND USE THEREOF

摘要

A novel thiol derivative that has a matrix metalloprotease inhibition activity and is useful as a drug, especially a therapeutic agent for arthrosis deformans and articular rheumatism. In particular, a compound of the formula: [I] [wherein the ring A is a substituted or unsubstituted aromatic heterocycle; the ring B is a substituted or unsubstituted homocycle or heterocycle; R<1> is a hydrogen atom, a substituted or unsubstituted hydrocarbon group, an acyl group, a substituted or unsubstituted heterocyclic group or SR<2> (R<2> is a hydrogen atom, a substituted or unsubstituted hydrocarbon group, an acyl group or a substituted or unsubstituted heterocyclic group); X is a substituted or unsubstituted divalent C1-3 aliphatic hydrocarbon group; Y is a substituted or unsubstituted hydrocarbon group, a halogen atom, a carboxyl group, an acyl group, a substituted or unsubstituted hydroxyl group, a substituted or unsubstituted amino group, SR<3> (R<3> is a hydrogen atom, a substituted or unsubstituted hydrocarbon group, an acyl group or a substituted or unsubstituted heterocyclic group), an oxo group, a thioxo group, a substituted or unsubstituted imino group, a nitro group or a cyano group; and q is an integer of 0 to 5] or a salt thereof.