| 摘要 |
The present invention provides composition of matter for and methods of treating pain and drug abuse using novel chimeric hybrid molecules containin g an opioid moiety of chemically modified morphine (3) that binds to and activates the human mu (~) opioid receptor, with the opioid moiety linked through a novel linker-hinge (4) to a substance P peptide fragment moiety (5 ) that binds to and activates the human substance P receptor. The hybrid alkaloid/peptide chimeric molecules produce clinically efficacious opioid analgesia with little or no development of opioid tolerance or formation of opioid dependence. The hybrid alkaloid/peptide analgesics may be administere d intrathecally, systemically or orally.
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