发明名称 |
Methods for generating databases and databases for identifying polymorphic genetic markers |
摘要 |
A method for discovery of a polymorphism in a population is provided. The method includes the steps of obtaining samples of body tissue or fluid from a plurality of organisms; isolating a biopolymer from each sample; pooling each isolated biopolymer; optionally amplifying the amount of biopolymer; cleaving the pooled biopolymers to produce fragments thereof; obtaining a mass spectrum of the resulting fragments; and comparing the frequency of each fragment to identify fragments present in amounts lower than the average frequency, thereby identifying any polymorphisms.
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申请公布号 |
US2003207297(A1) |
申请公布日期 |
2003.11.06 |
申请号 |
US20020273228 |
申请日期 |
2002.10.15 |
申请人 |
KOSTER HUBERT;BRAUN ANDREAS;BOOM DIRK VAN DEN;YIP PING;RODI CHARLIE;HE LIYAN;CHIU NORMAN;JURINKE CHRISTIAN |
发明人 |
KOSTER HUBERT;BRAUN ANDREAS;BOOM DIRK VAN DEN;YIP PING;RODI CHARLIE;HE LIYAN;CHIU NORMAN;JURINKE CHRISTIAN |
分类号 |
C12P19/34;C12Q1/68;G01N33/48;G01N33/50;G01N33/53;G06F19/00;(IPC1-7):C12Q1/68 |
主分类号 |
C12P19/34 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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