发明名称 |
Protein c derivatives |
摘要 |
Novel human protein C derivatives are described. These derivatives have increased anti-coagulation activity and resistance to inactivation by serpins compared to wild-type protein C and retain the biological activity of the wild-type human protein C. These derivatives will require either less frequent administration and/or smaller dosage than wild-type human protein C in the treatment of acute coronary syndromes, vascular occlusive disorders, hypercoagulable states, thrombotic disorders and disease states predisposing to thrombosis.
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申请公布号 |
US2003207435(A1) |
申请公布日期 |
2003.11.06 |
申请号 |
US20020168407 |
申请日期 |
2002.06.20 |
申请人 |
GERLITZ BRUCE EDWARD;JONES BRYAN EDWARD |
发明人 |
GERLITZ BRUCE EDWARD;JONES BRYAN EDWARD |
分类号 |
C12N15/09;A61K38/00;A61K38/43;A61K38/48;A61K45/00;A61K48/00;A61P7/02;A61P9/00;A61P9/08;A61P9/10;A61P31/04;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/50;C12N9/64;C12N15/57;C12R1/91;(IPC1-7):A61K38/48;C07H21/04;C12P21/02;C12N5/06 |
主分类号 |
C12N15/09 |
代理机构 |
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