Poloxamer and poloxamine compositions for nucleic acid delivery

摘要

The invention features selected polymers such as poloxamer 188 (Pluronic(R) F68), poloxamer 237 (Pluronic(R) F87), poloxamer 401 (Pluronic(R) L121), poloxamer 338 (Pluronic(R) F108), Poloxamer 124 (Pluronic(R) L44), Poloxamer 184 (L-64), and poloxamines (Tetronics(R) 904, 908, 1107, and 90R4) that enhance expression from nucleic acids when administered into an organism, in particular to muscle, and further provides selected poloxamer formulations for delivery of nucleic acids to the liver.