| 发明名称 |
1, 2-alpha-methylene 6, 7-alpha-dihalo-20-spirox-4-ene - -3-oxygenated derivs - as anti-androgenic agents |
| 摘要 |
<p>Title cpds. esp. the 6, 7 alpha-difluoro and dichloro-3-ones 3-ols and their 1-6C acylates are prepd. b y ring closing a 1, 2 alpha-methylene-6, 7 alpha-dihalomethylen-17 alpha-13-hydroxypropyl)-17 beta-hydroxy-andiost-4-en-3-one and opt. reducing the 3-one to the 3-ol and acylating this. The 6,7 alpha-difluoro-3-one is prepd. using p-tosyl chloride as cyclising agent.</p> |
| 申请公布号 |
BE779777(A4) |
申请公布日期 |
1972.08.24 |
| 申请号 |
BE19720779777 |
申请日期 |
1972.02.24 |
| 申请人 |
MERCK + CO. INC., 126, EAST LINCOLN AVENUE, RAHWAY, NEW JERSEY (E.U.A.), |
发明人 |
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| 分类号 |
C07J53/00;(IPC1-7):07D/;61K/ |
主分类号 |
C07J53/00 |
| 代理机构 |
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代理人 |
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| 主权项 |
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| 地址 |
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