SPIROBARBITURIC ACID DERIVATIVES USEFUL AS INHIBITORS OF MATRIX METALLOPROTEASES

摘要

Compound having the formula (I),wherein A, B and D are O or S; R1a and R1b are H, C1-4 alkyl, C2-4alkenyl; X is-NR2-,-S-,-S(=O)-, or -S(O)2-; G1, G2 and G3 are together or separately selected from hetero, carbonyl, alkylene, and alkenylene groups and G4 is optionally substituted methylene; R2 is Q-Ar, wherein Q is a linker and Ar is substituted or substituted aryl or heteroaryl; and z is 0 or 1, are useful as inhibitors of MMPs, particularly MMP-13, aggrecanase, and/or TACE.