发明名称 |
METHOD OF MODULATING OR EXAMINING KU70 LEVELS IN CELLS |
摘要 |
A method of predicting whether cells would respond to therapies which are mediated through Bax-regulated apoptosis is disclosed. In one embodiment, the method comprises the step of : (a) examining the intensity of the expression of the Bax protein or mRNA in a cell relative to a control, and (b) based on that intensity level, predicting whether cells will respond to therapies which are mediated through Bax-regulated apoptosis, wherein a high Bax level indicates that one may lower Ku70 levels and increase sensitivity to apoptosis. In another embodiment, the invention is a method of sensitizing cells to cancer therapy, comprising the step of reducing the cell's native Ku70 protein level. In another embodiment the invention is method of treating cell death-related diseases comprising the step of increasing cellular Ku70 protein level. |
申请公布号 |
WO03027237(A3) |
申请公布日期 |
2003.11.06 |
申请号 |
WO2002US29737 |
申请日期 |
2002.09.19 |
申请人 |
BLOOD CENTER RESEARCH FOUNDATION |
发明人 |
MATSUYAMA, SHIGEMI;SUN, WSEIYONG |
分类号 |
A61K38/00;C12N15/113;C12Q1/68 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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