IDENTIFICATION OF COMPOUNDS WHICH STIMULATE BONE FORMATION USING A CELL-BASED SCREENING ASSAY TARGETING BMP SIGNALING

摘要

Methods and compositions for measuring the effects of molecules which stimulate BMP and Cbfal signaling are disclosed, wherein the response elements in the Smad family and Cbfal are utilized in an assay system to modulate the production of an assayable product of a reporter construct.